GDNF/RET signalling in regulation of brain dopaminergic systems: significance for drug addiction
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منابع مشابه
Role of GDNF and its Cross-Talk with Other Growth Factors in the Dopaminergic System
1. Review of the literature ..........................................................................................1 1.1. Brain dopaminergic system ..................................................................................... 1 1.1.1. Development of the midbrain dopaminergic system ............................ 2 1.2. Parkinson’s disease...................................................
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Glial-cell-line-derived neurotrophic factor (GDNF) was originally identified as a survival factor for midbrain dopaminergic neurons. GDNF and related ligands, neurturin (NRTN), artemin (ARTN) and persephin (PSPN), maintain several neuronal populations in the central nervous systems, including midbrain dopamine neurons and motoneurons. In addition, GDNF, NRTN and ARTN support the survival and re...
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Glial cell line-derived neurotrophic factor, GDNF, is vital to the development and maintenance of neural tissues; it promotes survival of sympathetic, parasympathetic and spinal motor neurons during development, protects midbrain dopaminergic neurons from apoptosis well enough to be a promising treatment for Parkinson's disease, and controls renal and testicular development. Understanding how G...
متن کاملRET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice.
Glial cell-line derived neurotrophic factor (GDNF)-mediated RET tyrosine kinase signaling is implicated in the survival of several PNS and CNS neuronal populations that are important in the pathogenesis of several disorders including Parkinson's disease and drug addiction. However, it has been difficult to study these processes and the physiological importance of this pathway in adult mice beca...
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..................................................................................................................8 REVIEW OF THE LITERATURE ...............................................................................9 Introduction....................................................................................................................9 Glial cell line-derived neurotrophic factor f...
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